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Updated: Aug 02, 2026

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USMLE USMLE Exam Overview:

Certification Vendor:USMLE
Exam Name:United States Medical Licensing Examination
Exam Number:USMLE
Exam Price:USD 680
Passing Score:Pass/Fail (Step 1)
Related Certifications:USMLE Step 1
USMLE Step 2 Clinical Knowledge (CK)
USMLE Step 3
Real Exam Qty:Up to 280 (Step 1)
Certificate Validity Period:No fixed expiration; subject to individual state medical licensure requirements
Exam Format:Computer-based Examination, Multiple Choice Questions (MCQs), Single Best Answer Questions
Available Languages:English
Exam Duration:480 (Step 1)
Sample Questions:USMLE USMLE Sample Questions
Exam Way:Computer-based examination administered at Prometric test centers worldwide.
Pre Condition:Applicants must meet eligibility requirements established by USMLE, including enrollment in or graduation from an accredited medical school recognized by the appropriate authorities.
Official Syllabus URL:https://www.usmle.org/

Step 1 of the USMLE (United States Medical Licensing Examination) is the first part of the United States Medical Licensing Examination. It is open to medical school student and graduates to assess their ability to apply important concepts fundamental to the practice of medicine. While American medical students usually take USMLE Step 1 at the end of the second year of medical school, all graduates of foreign medical schools must take this exam is they intend to practice medicine in the United States.

USMLE Step 2 is a one-day (8 hours) exam. Similar to the Step 1, the test items are divided into blocks, and test item formats vary within each block, with the total number of exam questions equaling to 355.

USMLE Step 2 is open to all medical students and graduates who have successfully passed the USMLE Step 1. The Step 2 exam assesses the candidates' medical knowledge, skills, and understanding of clinical science essential for patient treatment and care, health promotion and disease prevention.

Reference: http://www.usmle.org/step-1/#question-formats

USMLE USMLE Exam Syllabus Topics:

SectionObjectives
Topic 1: Skin and Related Connective Tissue- Dermatologic Conditions
  • 1. Inflammatory Skin Disorders
  • 2. Skin Neoplasms
Topic 2: Respiratory System- Pulmonary Medicine
  • 1. Lung Diseases
  • 2. Airway Disorders
Topic 3: Cardiovascular System- Cardiac and Vascular Disorders
  • 1. Heart Disease
  • 2. Vascular Pathology
Topic 4: Human Development- Growth and Development
  • 1. Developmental Abnormalities
  • 2. Embryology
Topic 5: Gastrointestinal System- Digestive System Disorders
  • 1. Gastrointestinal Pathology
  • 2. Liver Disease
Topic 6: Musculoskeletal System- Bones, Joints, and Muscles
  • 1. Orthopedic Disorders
  • 2. Rheumatologic Diseases
Topic 7: Hematopoietic and Lymphoreticular Systems- Blood and Immune Disorders
  • 1. Anemias
  • 2. Coagulation Disorders
  • 3. Leukemias and Lymphomas
Topic 8: Multisystem Processes and Disorders- Systemic Conditions
  • 1. Infectious Diseases
  • 2. Neoplasia
  • 3. Nutrition
Topic 9: Endocrine System- Hormonal Regulation and Disease
  • 1. Thyroid Disorders
  • 2. Pituitary Disorders
  • 3. Adrenal Disorders
Topic 10: Central and Peripheral Nervous Systems- Neurologic Disorders
  • 1. Neurologic Diseases
  • 2. Neuroanatomy
  • 3. Neuropathology
Topic 11: Renal and Urinary System- Kidney and Urinary Disorders
  • 1. Renal Pathology
  • 2. Renal Physiology
Topic 12: Reproductive System- Male and Female Reproductive Health
  • 1. Reproductive Physiology
  • 2. Reproductive Disorders
Topic 13: General Principles- Foundational Medical Sciences
  • 1. Pathology
  • 2. Genetics
  • 3. Physiology
  • 4. Behavioral Sciences
  • 5. Biochemistry
  • 6. Immunology
  • 7. Pharmacology
  • 8. Microbiology

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Once download and installed on your PC, you can practice USMLE test questions, review your questions & answers using two different options 'practice exam' and 'virtual exam'.
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Online Test Engine can supports Windows / Mac / Android / iOS, etc., because it is the software based on WEB browser. You can use it on any electronic device and practice with self-paced.
Online Test Engine supports offline practice, while the precondition is that you should run it with the internet at the first time.
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PDF Version: can be read under the Adobe reader, or many other free readers, including OpenOffice, Foxit Reader and Google Docs.

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